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sparsentan will lower the level or impact of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Check. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and lowers efficacy associated with these substrates.Ferraro et al (1996) in the main of a series of papers about modafinil’s actions showed employing in